Issue 13, 2016

A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule

Abstract

We have constructed a ‘turn-off’ and label free bio-sensor using a DNAzyme molecule. This facile bio-sensor is capable of selective detection of mercuric ions with a high sensitivity and satisfactory dynamic range. More importantly, it is able to generate both fluorescent and colourimetric signals for detection. This dual-channel bio-sensor is expected to afford high detection confidence and overcome false-positive readout especially when assaying complex biological samples.

Graphical abstract: A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2016
Accepted
04 May 2016
First published
20 May 2016

Analyst, 2016,141, 3997-4000

A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule

L. Ma, H. Liu, G. Wu, N. Sun, L. Meng, Y. Li, Z. Liu and A. Diao, Analyst, 2016, 141, 3997 DOI: 10.1039/C6AN00795C

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