Issue 25, 2016

Application of a quinone-based fluorophore for spectrofluorimetric determination of albendazole in pure form and pharmaceutical formulations

Abstract

A spectrofluorimetric method was developed for the determination of albendazole (ALB) through charge transfer (CT) complex formation with 7,7,8,8-tetracyanoquinodimethane (TCNQ). TCNQ was found to react with ALB to produce a stable complex, and the fluorescence intensity of the complex was enhanced to 25 times higher than that of the studied drug itself. Different experimental parameters that affect the fluorescence intensity were carefully studied, at optimum reaction conditions, the drug–TCNQ complex showed an excitation maxima at 295 nm and an emission maxima at 476 nm. A rectilinear calibration graph was obtained in the concentration range of 100–800 ng ml−1. Thermodynamics parameters were calculated as: association constant KC of 7.28 × 103 mol−1 dm3 and a Gibbs free energy ΔG° of −4.66 kJ mol−1. The developed method was applied successfully to the determination of the studied drug in its pharmaceutical dosage form with good precision and accuracy compared to official and reported methods as revealed by t- and F-tests.

Graphical abstract: Application of a quinone-based fluorophore for spectrofluorimetric determination of albendazole in pure form and pharmaceutical formulations

Article information

Article type
Paper
Submitted
28 Oct 2015
Accepted
06 Jun 2016
First published
06 Jun 2016

Anal. Methods, 2016,8, 5136-5141

Application of a quinone-based fluorophore for spectrofluorimetric determination of albendazole in pure form and pharmaceutical formulations

K. A. M. Attia, A. A. Mohamad and M. S. Emara, Anal. Methods, 2016, 8, 5136 DOI: 10.1039/C5AY02845K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements