Electrochemical determination of mesalazine by using graphene oxide coated with a molecularly imprinted sol–gel

Abstract

Graphene oxide coated with a molecularly imprinted sol–gel was prepared by one-pot synthesis from phenyltriethoxysilane and tetramethoxysilane. The composite modified electrode was used for electrochemical determination of mesalazine (ASA) by differential pulse voltammetry (DPV) in Britton–Robinson buffer solution (pH = 2.0). The peak current was linear with the concentration in the range from 2 to 20 μmol L⁻¹ (r² = 0.9955) and 20 to 150 μmol L⁻¹ (r² = 0.9987) with a detection limit of 0.97 μmol L⁻¹ (S/N = 3). Interferents with similar structures such as salicylic acid, 4-aminophenol, 2-aminobenzoic acid and 4-acetamidophenol were examined. The utilizability and reliability of this method were confirmed by the determination of mesalazine in a drug tablet.