Issue 4, 2016
From the journal:

Chemical Communications

Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools†

Vincenzo Abbate,‡a   Olivier Reelfs,‡b   Xiaole Kong,a   Charareh Pourzandb  and  Robert C. Hider*a  

* Corresponding authors

a Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
E-mail: robert.hider@kcl.ac.uk
Fax: +44 (0)2078486394

b Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK

Abstract

Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

Graphical abstract: Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

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Article information

DOI
https://doi.org/10.1039/C5CC06170A
Article type
Communication
Submitted
23 Jul 2015
Accepted
09 Nov 2015
First published
09 Nov 2015

Chem. Commun., 2016,52, 784-787

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Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

V. Abbate, O. Reelfs, X. Kong, C. Pourzand and R. C. Hider, Chem. Commun., 2016, 52, 784 DOI: 10.1039/C5CC06170A

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