Issue 4, 2016
From the journal:

Chemical Communications

Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene†

A. M. Debela,ab   S. Thorimbert,b   B. Hasenknopf,b   C. K. O'Sullivan‡*ac  and  M. Ortiz*a  

* Corresponding authors

a Departament d'Enginyeria Química, Universitat Rovira i Virgili, Avinguda Països Catalans 26, 43007 Tarragona, Spain
E-mail: mayreli.ortiz@urv.cat, ckosulli@etse.urv.es

b Sorbonne Universités, UPMC Univ Paris 06 Institut Parisien de Chimie Moléculaire, UMR CNRS 8232, 4 place Jussieu, 75005 Paris, France

c ICREA, Passeig Lluis Companys 23, 08010 Barcelona, Spain

Abstract

We report the labelling of dideoxy nucleotides (ddNTPs) for use in electrochemical array based primer extension for the detection of single nucleotide polymorphisms (SNPs). The results confirm the extension of the immobilised primers for each of the four ddNTPs, representing a significant advance in achieving a cost-effective platform for screening of disease-specific SNPs.

Graphical abstract: Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

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Article information

DOI
https://doi.org/10.1039/C5CC07762A
Article type
Communication
Submitted
16 Sep 2015
Accepted
27 Oct 2015
First published
04 Nov 2015

Chem. Commun., 2016,52, 757-759

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Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

A. M. Debela, S. Thorimbert, B. Hasenknopf, C. K. O'Sullivan and M. Ortiz, Chem. Commun., 2016, 52, 757 DOI: 10.1039/C5CC07762A

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