Issue 1, 2016
From the journal:

Chemical Communications

Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement†

Qiang Sha,ab   Hadi Armanb  and  Michael P. Doyle*b  

* Corresponding authors

a School of Chemical Engineering, Nanjing University of Science and Technology, Xiao Ling Wei 200, Nanjing 210094, P. R. China

b Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
E-mail: michael.doyle@utsa.edu

Abstract

An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2,3-diketoesters has been developed.

Graphical abstract: Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement

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Article information

DOI
https://doi.org/10.1039/C5CC07780J
Article type
Communication
Submitted
16 Sep 2015
Accepted
14 Oct 2015
First published
16 Oct 2015

Chem. Commun., 2016,52, 108-111

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Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement

Q. Sha, H. Arman and M. P. Doyle, Chem. Commun., 2016, 52, 108 DOI: 10.1039/C5CC07780J

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