A versatile water-soluble chelating and radical scavenging platform

Meital Eckshtain-Levi; Ronit Lavi; Dmitry S. Yufit; Bareket Daniel; Omer Green; Ohad Fleker; Michal Richman; Shai Rahimipour; Arie Gruzman; Laurent Benisvy

doi:10.1039/C5CC08198J

A versatile water-soluble chelating and radical scavenging platform†

Meital Eckshtain-Levi,^a Ronit Lavi,^a Dmitry S. Yufit,^b Bareket Daniel,^a Omer Green,^a Ohad Fleker,^a Michal Richman,^a Shai Rahimipour,^a Arie Gruzman*^a and Laurent Benisvy*^a

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^a Department of Chemistry, Bar-Ilan University, Ramat Gan 52900, Israel
E-mail: benisvy@gmail.com, gruzmaa@biu.ac.il

^b Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK

Abstract

The phenol-diamide compound, 5-(tert-butyl)-2-hydroxy-N1,N3-bis(2-hydroxyethyl)isophthalamide (1OH), is water-soluble, non-cytotoxic, and capable of both, trapping ROS species and chelating Cu(II) and Fe(III) ions; these combined properties confer a protective effect against ROS induced cell death.

Chemical Communications

A versatile water-soluble chelating and radical scavenging platform†

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A versatile water-soluble chelating and radical scavenging platform

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