Issue 4, 2016

Regioselective modification of unprotected glycosides

Abstract

Selective modification of unprotected carbohydrates is difficult due to the similar reactivity of the hydroxyl groups. In carbohydrate synthesis, therefore, even straightforward transformations often require multiple synthetic steps. The development of selective methods for carbohydrate modification is consequently highly desired. This review describes the methods for the regio- and chemoselective carbohydrate modification, with a focus on novel approaches that mainly apply transition metal catalysis and organocatalysis, and discusses the challenges and opportunities in this field.

Graphical abstract: Regioselective modification of unprotected glycosides

Article information

Article type
Feature Article
Submitted
01 Oct 2015
Accepted
09 Nov 2015
First published
09 Nov 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 656-664

Author version available

Regioselective modification of unprotected glycosides

M. Jäger and A. J. Minnaard, Chem. Commun., 2016, 52, 656 DOI: 10.1039/C5CC08199H

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