Issue 1, 2016
From the journal:

Chemical Communications

Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH†

Samit Guha,a   Gillian Karen Shaw,a   Trevor M. Mitcham,b   Richard R. Bouchardb  and  Bradley D. Smith*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, IN 46556, USA
E-mail: smith.115@nd.edu

b Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA

Abstract

Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.

Graphical abstract: Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH

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Article information

DOI
https://doi.org/10.1039/C5CC08317F
Article type
Communication
Submitted
06 Oct 2015
Accepted
20 Oct 2015
First published
22 Oct 2015

Chem. Commun., 2016,52, 120-123

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Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH

S. Guha, G. K. Shaw, T. M. Mitcham, R. R. Bouchard and B. D. Smith, Chem. Commun., 2016, 52, 120 DOI: 10.1039/C5CC08317F

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