A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.
P. Marcé, J. Lynch, A. J. Blacker and J. M. J. Williams, Chem. Commun., 2016, 52, 1436 DOI: 10.1039/C5CC08714G
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