Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

Tao Yang; Xiaohui Wang; Changli Zhang; Xiang Ma; Kun Wang; Yanqing Wang; Jian Luo; Liu Yang; Cheng Yao; Xiaoyong Wang

doi:10.1039/C5CC08898D

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator†

Tao Yang,‡^a Xiaohui Wang,‡*^ab Changli Zhang,^c Xiang Ma,^b Kun Wang,^b Yanqing Wang,^d Jian Luo,^a Liu Yang,^a Cheng Yao*^a and Xiaoyong Wang*^e

Author affiliations

* Corresponding authors

^a College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China
E-mail: wangxhui@njtech.edu.cn, yaocheng@njtech.edu.cn

^b State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China

^c Department of Chemistry, Nanjing Xiaozhuang College, Nanjing, P. R. China

^d School of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng 224002, P. R. China

^e State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, P. R. China
E-mail: boxwxy@nju.edu.cn

Abstract

A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.

Chemical Communications

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

Social activity

Search articles by author

Spotlight

Advertisements