Issue 11, 2016
From the journal:

Chemical Communications

Nanoparticle delivery of sterically hindered platinum(iv) prodrugs shows 100 times higher potency than that of cisplatin upon light activation†

Haiqin Song,‡ab   Xiang Kang,‡c   Jing Sun,ab   Xiabin Jing,d   Zehua Wang,c   Lesan Yan,*de   Ruogu Qi*de  and  Minhua Zheng*ab  

* Corresponding authors

a Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 People's Republic of China
E-mail: zmhtiger@yeah.net

b Shanghai Minimally Invasive Surgery Center, Shanghai, 200025 P. R. China

c Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China

d State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China
E-mail: Ruoguqix@gmail.com, Lesanyan@gmail.com

e The University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

The introduction of a sterically hindered pyridine ligand to a photosensitive platinum(IV) drug for drug delivery resulted in a >100 fold increase in effectiveness compared to the gold standard, cisplatin.

Graphical abstract: Nanoparticle delivery of sterically hindered platinum(iv) prodrugs shows 100 times higher potency than that of cisplatin upon light activation

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Article information

DOI
https://doi.org/10.1039/C5CC09534D
Article type
Communication
Submitted
17 Nov 2015
Accepted
03 Dec 2015
First published
07 Dec 2015

Chem. Commun., 2016,52, 2281-2283

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Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation

H. Song, X. Kang, J. Sun, X. Jing, Z. Wang, L. Yan, R. Qi and M. Zheng, Chem. Commun., 2016, 52, 2281 DOI: 10.1039/C5CC09534D

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