Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

D. E. Korenchan; R. R. Flavell; C. Baligand; R. Sriram; K. Neumann; S. Sukumar; H. VanBrocklin; D. B. Vigneron; D. M. Wilson; J. Kurhanewicz

doi:10.1039/C5CC09724J

Dynamic nuclear polarization of biocompatible ¹³C-enriched carbonates for in vivo pH imaging†

D. E. Korenchan,

^ab R. R. Flavell,

^b C. Baligand,^b R. Sriram,^b K. Neumann,^b S. Sukumar,^b H. VanBrocklin,^b D. B. Vigneron,^ab D. M. Wilson*^b and J. Kurhanewicz*^ab

Author affiliations

* Corresponding authors

^a UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA
E-mail: john.kurhanewicz@ucsf.edu

^b Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
E-mail: david.m.wilson@ucsf.edu

Abstract

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized ¹³C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized ¹³C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

Chemical Communications

Dynamic nuclear polarization of biocompatible ¹³C-enriched carbonates for in vivo pH imaging†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Dynamic nuclear polarization of biocompatible ¹³C-enriched carbonates for in vivo pH imaging

Social activity

Search articles by author

Spotlight

Advertisements

Chemical Communications