Organic phosphate metabolites contain functional groups with pKa values near the physiologic pH range, yielding pH-dependent 13C chemical shift changes of adjacent quaternary carbon sites. When formed in defined cellular compartments from exogenous hyperpolarised 13C substrates, metabolites can thus yield localised pH values and correlations of organelle pH and catalytic activity.
P. R. Jensen and S. Meier, Chem. Commun., 2016, 52, 2288 DOI: 10.1039/C5CC09790H
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