Issue 20, 2016
From the journal:

Chemical Communications

Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA†

Xiongqi Han,‡a   Qixian Chen,‡b   Hongguang Lu,a   Pan Guo,a   Wei Li,a   Guolin Wu,c   Jianbiao Maa  and  Hui Gao*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, Tianjin 300384, China
E-mail: ghhigher@hotmail.com, hgao@tjut.edu.cn

b Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

c Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin, China

Abstract

A fluorophore displaying aggregation-induced emission was introduced at the terminus of branched polyethylenimine (PEI). The formulated polyplex not only demonstrated an improved safety profile and preserved transfection activity but also importantly indicated that the uncomplexed naked DNA rather than the polyplexes translocated into the nucleus.

Graphical abstract: Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA

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Article information

DOI
https://doi.org/10.1039/C5CC09836J
Article type
Communication
Submitted
28 Nov 2015
Accepted
13 Jan 2016
First published
15 Jan 2016

Chem. Commun., 2016,52, 3907-3910

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Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA

X. Han, Q. Chen, H. Lu, P. Guo, W. Li, G. Wu, J. Ma and H. Gao, Chem. Commun., 2016, 52, 3907 DOI: 10.1039/C5CC09836J

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