Issue 11, 2016
From the journal:

Chemical Communications

A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model†

Yaping Liu,a   Huilong Ma,a   Liangwei Zhang,a   Yajing Cui,a   Xiaoting Liua  and  Jianguo Fang*a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: fangjg@lzu.edu.cn

Abstract

The first off–on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.

Graphical abstract: A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

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Article information

DOI
https://doi.org/10.1039/C5CC09998F
Article type
Communication
Submitted
04 Dec 2015
Accepted
21 Dec 2015
First published
22 Dec 2015

Chem. Commun., 2016,52, 2296-2299

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A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

Y. Liu, H. Ma, L. Zhang, Y. Cui, X. Liu and J. Fang, Chem. Commun., 2016, 52, 2296 DOI: 10.1039/C5CC09998F

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