Issue 29, 2016
From the journal:

Chemical Communications

A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates†

Julian Haas,a   Michael A. Schätzle,a   Syed M. Husain, ORCID logo ‡a   Johannes Schulz-Fincke,abc   Manfred Jung,a   Werner Hummel,d   Michael Müllera  and  Steffen Lüdeke ORCID logo *a  

* Corresponding authors

a Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany
E-mail: steffen.luedeke@pharmazie.uni-freiburg.de

b German Cancer Consortium (DKTK), Freiburg, Germany

c German Cancer Research Centre (DKFZ), Heidelberg, Germany

d Institute of Molecular Enzyme Technology, Heinrich-Heine-University of Düsseldorf, Research Centre Jülich, Stetternicher Forst, 52426 Jülich, Germany

Abstract

Spontaneous electron transport to molecular oxygen led to regeneration of oxidised nicotinamide cofactor in cell lysates that contain an alcohol dehydrogenase, a quinone reductase and a quinone mediator. This concept allows the efficient oxidation of alcohols in the presence of alcohol dehydrogenase-containing E. coli lysates and catalytic amounts of the quinone lawsone.

Graphical abstract: A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates

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Article information

DOI
https://doi.org/10.1039/C5CC10316A
Article type
Communication
Submitted
11 Jan 2016
Accepted
15 Mar 2016
First published
15 Mar 2016

Chem. Commun., 2016,52, 5198-5201

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A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates

J. Haas, M. A. Schätzle, S. M. Husain, J. Schulz-Fincke, M. Jung, W. Hummel, M. Müller and S. Lüdeke, Chem. Commun., 2016, 52, 5198 DOI: 10.1039/C5CC10316A

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