Rational design of multifunctional small-molecule prodrugs for simultaneous suppression of cancer cell growth and metastasis in vitro and in vivo

Abstract

We present a design concept for multifunctional prodrugs that simultaneously induce apoptosis and suppress cancer cell metastasis in vitro and in vivo. These “all-in-one” prodrug constructs possess therapeutic potential as novel “integrative” platforms for metastatic cancer treatment.