When direct host–guest binding interactions are weakened by unfavorable solvent competition, guest-triggered intrareceptor interactions could be used to augment the binding. This strategy of cooperative enhancement, when combined with the principle of preorganization, yielded a strong and selective receptor for binding citrate in water.
R. W. Gunasekara and Y. Zhao, Chem. Commun., 2016, 52, 4345 DOI: 10.1039/C5CC10405J
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