Issue 17, 2016
From the journal:

Chemical Communications

Detection of C-reactive protein using nanoparticle-enhanced surface plasmon resonance using an aptamer-antibody sandwich assay†

Bin Wu,‡a   Rui Jiang,‡a   Qing Wang,a   Jin Huang,a   Xiaohai Yang,*a   Kemin Wang,*a   Wenshan Li,a   Nandi Chena  and  Qing Lia  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Hunan University, Changsha, China
E-mail: yangxiaohai@hnu.edu.cn, kmwang@hnu.edu.cn
Fax: +86 731 88821566
Tel: +86 731 88821566

Abstract

High affinity DNA aptamers against C-reactive protein (CRP) were obtained using a microfluidic chip. The aptamers were then used for the construction of an Au nanoparticle enhanced surface plasmon resonance biosensor, which was introduced for the detection of CRP at concentrations ranging from 10 pM to 100 nM in diluted human serum.

Graphical abstract: Detection of C-reactive protein using nanoparticle-enhanced surface plasmon resonance using an aptamer-antibody sandwich assay

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Article information

DOI
https://doi.org/10.1039/C5CC10486F
Article type
Communication
Submitted
22 Dec 2015
Accepted
27 Jan 2016
First published
27 Jan 2016

Chem. Commun., 2016,52, 3568-3571

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Detection of C-reactive protein using nanoparticle-enhanced surface plasmon resonance using an aptamer-antibody sandwich assay

B. Wu, R. Jiang, Q. Wang, J. Huang, X. Yang, K. Wang, W. Li, N. Chen and Q. Li, Chem. Commun., 2016, 52, 3568 DOI: 10.1039/C5CC10486F

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