Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids

Graham A. E. Garnett; Kevin D. Daze; Jorge A. Peña Diaz; Noah Fagen; Alok Shaurya; Manuel C. F. Ma; Mary S. Collins; Darren W. Johnson; Lev N. Zakharov; Fraser Hof

doi:10.1039/C5CC10527G

Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids†

Graham A. E. Garnett,^a Kevin D. Daze,^a Jorge A. Peña Diaz,^a Noah Fagen,^a Alok Shaurya,^a Manuel C. F. Ma,^a Mary S. Collins,^b Darren W. Johnson,^b Lev N. Zakharov^c and Fraser Hof*^a

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^a Department of Chemistry, University of Victoria, PO Box 3065, STN CSC, Victoria, Canada
E-mail: fhof@uvic.ca

^b Department of Chemistry & Biochemistry, University of Oregon, Eugene, Oregon, USA

^c Center for Advanced Materials Characterization in Oregon (CAMCOR), 1241 University of Oregon, Eugene, OR 97403-1241, USA

Abstract

We report a family of highly anionic calixarenes that form discrete homo-dimeric assemblies in pure water, that get stronger in high salt solutions, and that remain assembled in complex, denaturing solutions like real urine. The results reveal the potential of like-charged subunits for self-assembly in high-salt solutions and biological fluids.

Chemical Communications

Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids†

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Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids

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