A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants

Yi-Ru Wang; Lei Feng; Liang Xu; Yan Li; Dan-Dan Wang; Jie Hou; Kun Zhou; Qiang Jin; Guang-Bo Ge; Jing-Nan Cui; Ling Yang

doi:10.1039/C6CC00119J

A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants†

Yi-Ru Wang,‡^ab Lei Feng,‡^c Liang Xu,‡^d Yan Li,^a Dan-Dan Wang,^a Jie Hou,^b Kun Zhou,^a Qiang Jin,^b Guang-Bo Ge,*^ac Jing-Nan Cui*^c and Ling Yang*^a

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* Corresponding authors

^a Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
E-mail: geguangbo@dicp.ac.cn, lingdicp@gmail.com

^b Dalian Medical University, Dalian 116044, China

^c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
E-mail: jncui@dlut.edu.cn

^d School of Chemistry, Dalian University of Technology, Dalian, China

Abstract

A rapid-response fluorescent probe ACDM was developed for the selective and sensitive detection of human albumin (HA) via binding onto a non-drug binding site. ACDM was successfully used to detect trace HA in various biological samples including diluted plasma and cell culture supernatants.

Chemical Communications

A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants†

Abstract

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A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants

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