Issue 27, 2016

Metal ion triggers for reversible switching of DNA polymerase

Abstract

We herein develop a new strategy that modulates DNA polymerase activity in a reversible and switchable manner by using the novel interactions between DNA bases and metal ions (T–Hg2+–T and C–Ag+–C) inside a DNA aptamer capable of inhibiting DNA polymerase.

Graphical abstract: Metal ion triggers for reversible switching of DNA polymerase

Supplementary files

Article information

Article type
Communication
Submitted
17 Jan 2016
Accepted
17 Feb 2016
First published
17 Feb 2016

Chem. Commun., 2016,52, 4868-4871

Metal ion triggers for reversible switching of DNA polymerase

K. S. Park, C. Y. Lee and H. G. Park, Chem. Commun., 2016, 52, 4868 DOI: 10.1039/C6CC00454G

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