Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Z. Zhang; B. Schepens; L. Nuhn; X. Saelens; M. Schotsaert; N. Callewaert; R. De Rycke; Q. Zhang; S. Moins; S. Benali; L. Mespouille; R. Hoogenboom; B. G. De Geest

doi:10.1039/C6CC00501B

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination†

Z. Zhang,^a B. Schepens,^bc L. Nuhn,^a X. Saelens,^bc M. Schotsaert,^bc N. Callewaert,^bc R. De Rycke,^bc Q. Zhang,^d S. Moins,^e S. Benali,^e L. Mespouille,^e R. Hoogenboom^d and B. G. De Geest*^a

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* Corresponding authors

^a Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium
E-mail: br.degeest@ugent.be

^b Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium

^c Inflammation Research Center, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium

^d Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Krijgslaan 281, 9000 Ghent, Belgium

^e Laboratory of Polymeric & Composite Materials, Ctr Innovat & Res Mat & Polymers (CIRMAP), Material Res Inst. and Health Res. Inst., University of Mons, B-7000 Mons, Belgium

Abstract

We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol–gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.

Chemical Communications

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination†

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Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

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