Issue 19, 2016
From the journal:

Chemical Communications

Copper-catalyzed borylative coupling of vinylazaarenes and N-Boc imines†

Joshua J. Smith,ab   Daniel Bestab  and  Hon Wai Lam*ab  

* Corresponding authors

a EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, David Brewster Road, Edinburgh, UK

b School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: hon.lam@nottingham.ac.uk

Abstract

Cu-catalyzed three-component couplings of vinylazaarenes, B2(pin)2, and N-Boc imines are described. Oxidation of the initially formed boronate gives azaarene-containing, Boc-protected amino alcohols with reasonable to good diastereoselectivities.

Graphical abstract: Copper-catalyzed borylative coupling of vinylazaarenes and N-Boc imines

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Article information

DOI
https://doi.org/10.1039/C6CC00603E
Article type
Communication
Submitted
21 Jan 2016
Accepted
09 Feb 2016
First published
17 Feb 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 3770-3772

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Copper-catalyzed borylative coupling of vinylazaarenes and N-Boc imines

J. J. Smith, D. Best and H. W. Lam, Chem. Commun., 2016, 52, 3770 DOI: 10.1039/C6CC00603E

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