Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

D. Katayev; J. Václavík; F. Brüning; B. Commare; A. Togni

doi:10.1039/C6CC00700G

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Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation†

D. Katayev,^a J. Václavík,^ab F. Brüning,^a B. Commare^a and A. Togni

*^a

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* Corresponding authors

^a Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland
E-mail: atogni@ethz.ch

^b Institute of Organic Chemistry and Biochemistry, v.v.i. Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague, Czech Republic

Abstract

Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.

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DOI: https://doi.org/10.1039/C6CC00700G
Article type: Communication
Submitted: 24 Jan 2016
Accepted: 12 Feb 2016
First published: 12 Feb 2016

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Chem. Commun., 2016,52, 4049-4052

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Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

D. Katayev, J. Václavík, F. Brüning, B. Commare and A. Togni, Chem. Commun., 2016, 52, 4049 DOI: 10.1039/C6CC00700G

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Chemical Communications

Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation†

Abstract

Supplementary files

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Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

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