A novel dual-emission fluorescent probe for the simultaneous detection of H2S and GSH

H. Li; W. Peng; W. Feng; Y. Wang; G. Chen; S. Wang; S. Li; H. Li; K. Wang; J. Zhang

doi:10.1039/C6CC00973E

A novel dual-emission fluorescent probe for the simultaneous detection of H₂S and GSH†

H. Li,^a W. Peng,^a W. Feng,^a Y. Wang,^a G. Chen,^a S. Wang,*^ab S. Li,^a H. Li,^a K. Wang^a and J. Zhang*^ab

* Corresponding authors

^a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China

^b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China
E-mail: jczhang6970@163.com, wsx@hbu.edu.cn

Abstract

A novel chlorinated coumarin–malononitrile fluorescent probe with three potential reaction sites, which exhibited highly selective, rapid response, low detection limit, and was capable of the simultaneous detection of H₂S (λ_ex/em = 515/564 nm) and GSH (λ_ex/em = 430/517 nm), was first proposed. The probe was successfully applied to dual-channel imaging H₂S and GSH in MCF-7 cells.

Chemical Communications

A novel dual-emission fluorescent probe for the simultaneous detection of H₂S and GSH†

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A novel dual-emission fluorescent probe for the simultaneous detection of H₂S and GSH

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Chemical Communications