Issue 33, 2016
From the journal:

Chemical Communications

Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray†

Yixia Qian,‡abc   Weizhi Wang,‡*a   Zihua Wang,a   Qiuju Han,ad   Xiangqian Jia,ad   Shu Yanga  and  Zhiyuan Hu*a  

* Corresponding authors

a CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
E-mail: wangwz@nanoctr.cn, huzy@nanoctr.cn

b University of Chinese Academy of Science, No. 19A Yuquan Road, Beijing 100049, China

c Sino-Danish Center for Education and Research, Beijing, China

d Pharmacy College, Liaoning Medical University, Jinzhou, Liaoning 121001, China

Abstract

One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be “turned on” and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.

Graphical abstract: Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC01302C
Article type
Communication
Submitted
13 Feb 2016
Accepted
22 Mar 2016
First published
22 Mar 2016

Chem. Commun., 2016,52, 5690-5693

Author version available

Download author version (PDF)

Permissions

Request permissions

Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

Y. Qian, W. Wang, Z. Wang, Q. Han, X. Jia, S. Yang and Z. Hu, Chem. Commun., 2016, 52, 5690 DOI: 10.1039/C6CC01302C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements