Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies.
P. C. Knipe, S. Thompson and A. D. Hamilton, Chem. Commun., 2016, 52, 6521 DOI: 10.1039/C6CC01496H
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