Issue 48, 2016
From the journal:

Chemical Communications

Multi-component self-assembled anti-tumor nano-vaccines based on MUC1 glycopeptides†

Z. Y. Sun,a   P. G. Chen,a   Y. F. Liu,a   B. D. Zhang,a   J. J. Wu,a   Y. X. Chen,a   Y. F. Zhaoa  and  Y. M. Li*a  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
E-mail: liym@mail.tsinghua.edu.cn
Fax: +86-10-62781695

Abstract

Novel multi-component self-assembled nano-vaccines containing both Pam3CSK4 and CpG were developed for the first time. These multi-component vaccines could effectively activate the macrophages in vitro and elicit strong antibody immune responses and anti-tumor immune responses in vivo.

Graphical abstract: Multi-component self-assembled anti-tumor nano-vaccines based on MUC1 glycopeptides

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Article information

DOI
https://doi.org/10.1039/C6CC02000C
Article type
Communication
Submitted
07 Mar 2016
Accepted
17 May 2016
First published
17 May 2016

Chem. Commun., 2016,52, 7572-7575

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Multi-component self-assembled anti-tumor nano-vaccines based on MUC1 glycopeptides

Z. Y. Sun, P. G. Chen, Y. F. Liu, B. D. Zhang, J. J. Wu, Y. X. Chen, Y. F. Zhao and Y. M. Li, Chem. Commun., 2016, 52, 7572 DOI: 10.1039/C6CC02000C

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