Issue 40, 2016
From the journal:

Chemical Communications

Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and in vivo†

Xiaojun Liu,a   Bo Hu,a   Ranran Cheng,a   Fanpeng Kong,a   Xiaohong Pan,a   Kehua Xu*a  and  Bo Tang*a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn, xukehua@sdnu.edu.cn

Abstract

Based on the rapid substitution reaction of the Au–S bond by selenol, we designed and synthesized a nanoprobe 5-FAM-peptide-AuNPs for selenol. Real-time imaging shows that this probe together with the molecular probe QCy7-H2O2 is able to simultaneously and differentially monitor the concentrations of selenol and H2O2 in living cells and in vivo.

Graphical abstract: Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and in vivo

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Article information

DOI
https://doi.org/10.1039/C6CC02111E
Article type
Communication
Submitted
10 Mar 2016
Accepted
19 Apr 2016
First published
19 Apr 2016

Chem. Commun., 2016,52, 6693-6696

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Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and in vivo

X. Liu, B. Hu, R. Cheng, F. Kong, X. Pan, K. Xu and B. Tang, Chem. Commun., 2016, 52, 6693 DOI: 10.1039/C6CC02111E

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