Issue 41, 2016
From the journal:

Chemical Communications

Proof of concept for inhibiting metastasis: circulating tumor cell-triggered localized release of anticancer agent via a structure-switching aptamer†

Nandi Chen,a   Xiaohai Yang,*a   Qing Wang,a   Lixin Jian,a   Hui Shi,a   Shiya Qin,a   Kemin Wang,*a   Jin Huanga  and  Wenjing Liua  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China
E-mail: kmwang@hnu.edu.cn, yangxiaohai@hnu.edu.cn

Abstract

Existing drug delivery systems were not suitable for killing cells in the circulatory system specifically. Herein, we developed a novel localized drug delivery strategy, in which the release of anticancer agents was specifically triggered by circulating tumor cells. Meanwhile, damage to non-target cells was avoided.

Graphical abstract: Proof of concept for inhibiting metastasis: circulating tumor cell-triggered localized release of anticancer agent via a structure-switching aptamer

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Article information

DOI
https://doi.org/10.1039/C6CC02374F
Article type
Communication
Submitted
18 Mar 2016
Accepted
19 Apr 2016
First published
20 Apr 2016

Chem. Commun., 2016,52, 6789-6792

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Proof of concept for inhibiting metastasis: circulating tumor cell-triggered localized release of anticancer agent via a structure-switching aptamer

N. Chen, X. Yang, Q. Wang, L. Jian, H. Shi, S. Qin, K. Wang, J. Huang and W. Liu, Chem. Commun., 2016, 52, 6789 DOI: 10.1039/C6CC02374F

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