A decahaem cytochrome as an electron conduit in protein–enzyme redox processes

Chong-Yong Lee; Bertrand Reuillard; Katarzyna P. Sokol; Theodoros Laftsoglou; Colin W. J. Lockwood; Sam F. Rowe; Ee Taek Hwang; Juan C. Fontecilla-Camps; Lars J. C. Jeuken; Julea N. Butt; Erwin Reisner

doi:10.1039/C6CC02721K

A decahaem cytochrome as an electron conduit in protein–enzyme redox processes†

Chong-Yong Lee,‡§^a Bertrand Reuillard,‡^a Katarzyna P. Sokol,^a Theodoros Laftsoglou,^b Colin W. J. Lockwood,^c Sam F. Rowe,^c Ee Taek Hwang,

^b Juan C. Fontecilla-Camps,^d Lars J. C. Jeuken,*^b Julea N. Butt*^c and Erwin Reisner*^a

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* Corresponding authors

^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
E-mail: reisner@ch.cam.ac.uk

^b School of Biomedical Sciences and the Astbury Centre, University of Leeds, Leeds, UK
E-mail: l.j.c.jeuken@leeds.ac.uk

^c School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, UK
E-mail: j.butt@uea.ac.uk

^d Metalloproteins Unit, Institut de Biologie Structurale, CEA, CNRS, Université Grenoble Alpes, 38044 Grenoble, France

Abstract

The decahaem cytochrome MtrC from Shewanella oneidensis MR-1 was employed as a protein electron conduit between a porous indium tin oxide electrode and redox enzymes. Using a hydrogenase and a fumarate reductase, MtrC was shown as a suitable and efficient diode to shuttle electrons to and from the electrode with the MtrC redox activity regulating the direction of the enzymatic reactions.

Chemical Communications

A decahaem cytochrome as an electron conduit in protein–enzyme redox processes†

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A decahaem cytochrome as an electron conduit in protein–enzyme redox processes

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