Catalytic enzyme-linked click-chemistry assays (cat-ELCCA) are an emerging class of biochemical assay. Herein we report on expanding the toolkit of cat-ELCCA to include the kinetically superior inverse-electron demand Diels–Alder (IEDDA) reaction. The result is a technology with improved sensitivity and reproducibility, enabling automated high-throughput screening.
D. A. Lorenz and A. L. Garner, Chem. Commun., 2016, 52, 8267 DOI: 10.1039/C6CC02894B
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