Issue 52, 2016

Octahedral ruthenium complexes selectively stabilize G-quadruplexes

Abstract

A series of octahedral Ru(II) complexes with an xy planar tetradentate and two trans-z-axis ammonia ligands were synthesized. High stabilization of G-quadruplexes was achieved upon π-stacking with aromatic planar ligands. Unique interaction from z-axis ligands bestowed both excellent binding resistance to duplex DNA and selectivity towards the antiparallel topology.

Graphical abstract: Octahedral ruthenium complexes selectively stabilize G-quadruplexes

Supplementary files

Article information

Article type
Communication
Submitted
14 Apr 2016
Accepted
31 May 2016
First published
31 May 2016

Chem. Commun., 2016,52, 8095-8098

Octahedral ruthenium complexes selectively stabilize G-quadruplexes

L. He, X. Chen, Z. Meng, J. Wang, K. Tian, T. Li and F. Shao, Chem. Commun., 2016, 52, 8095 DOI: 10.1039/C6CC03117J

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