Octahedral ruthenium complexes selectively stabilize G-quadruplexes†
Abstract
A series of octahedral Ru(II) complexes with an x–y planar tetradentate and two trans-z-axis ammonia ligands were synthesized. High stabilization of G-quadruplexes was achieved upon π-stacking with aromatic planar ligands. Unique interaction from z-axis ligands bestowed both excellent binding resistance to duplex DNA and selectivity towards the antiparallel topology.