Issue 60, 2016

Decarboxylative Csp3–Csp3 coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols

Abstract

A new decarboxylative Csp3–Csp3 coupling approach for the benzylation of ketone enolates has been developed. A variety of raspberry ketone derivatives were conveniently synthesized in good to excellent yields under mild conditions. A crossover reaction shed light on the mechanism of this tandem reaction.

Graphical abstract: Decarboxylative Csp3–Csp3 coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
07 May 2016
Accepted
27 Jun 2016
First published
27 Jun 2016

Chem. Commun., 2016,52, 9454-9457

Decarboxylative Csp3–Csp3 coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols

S. Wang, X. Chen, Q. Ao, H. Wang and H. Zhai, Chem. Commun., 2016, 52, 9454 DOI: 10.1039/C6CC03835B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements