We describe a novel class of amphiphiles with squaramide moiety as a phosphate bioisostere. Most synthesized squaramide-based amphiphiles have the favorable physicochemical properties of lipids, such as: formation of stable liposomes or giant unilamellar vesicles in aqueous solution, high phase-transition temperature, low vesicle leakage and phospholipase resistance properties.
A. Saha, S. Panda, S. Paul and D. Manna, Chem. Commun., 2016, 52, 9438 DOI: 10.1039/C6CC04089F
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