Enantioselective synthesis of quaternary α-aminophosphonates by Pd-catalyzed arylation of cyclic α-ketiminophosphonates with arylboronic acids

Abstract

A highly enantioselective addition of arylboronic acids to cyclic α-ketiminophosphonates is reported using a chiral palladium phosphinooxazoline catalyst, providing an efficient and facile route to quaternary α-aminophosphonates in high yields and up to 99.9% enantioselectivity.