Issue 52, 2016

Exploring substrate scope and stereoselectivity of P450 peroxygenase OleTJE in olefin-forming oxidative decarboxylation

Abstract

As recently reported, the olefin-forming oxidative decarboxylation of straight-chain C4–C22 carboxylic acids catalyzed by P450 peroxygenase OleTJE constitutes a mild alkene synthesis. The present study shows that structurally different carboxylic acids are also accepted, including those that generate di-substituted olefins. Exploratory mutational experiments lead to increased trans-selectivity.

Graphical abstract: Exploring substrate scope and stereoselectivity of P450 peroxygenase OleTJE in olefin-forming oxidative decarboxylation

Supplementary files

Article information

Article type
Communication
Submitted
24 May 2016
Accepted
03 Jun 2016
First published
03 Jun 2016

Chem. Commun., 2016,52, 8131-8133

Exploring substrate scope and stereoselectivity of P450 peroxygenase OleTJE in olefin-forming oxidative decarboxylation

J. Wang, R. Lonsdale and M. T. Reetz, Chem. Commun., 2016, 52, 8131 DOI: 10.1039/C6CC04345C

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