A novel approach to design bimetallic anticancer drug candidates with the capability to combat both drug resistance and tumor metastasis is reported. These water-soluble bifunctional Pt(IV)–Ru(II) heterodinuclear complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.
L. Ma, R. Ma, Z. Wang, S. Yiu and G. Zhu, Chem. Commun., 2016, 52, 10735 DOI: 10.1039/C6CC04354B
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