Targeted fluorescence imaging enhanced by 2D materials: a comparison between 2D MoS2 and graphene oxide

Donghao Xie; Ding-Kun Ji; Yue Zhang; Jun Cao; Hu Zheng; Lin Liu; Yi Zang; Jia Li; Guo-Rong Chen; Tony D. James; Xiao-Peng He

doi:10.1039/C6CC04687H

Targeted fluorescence imaging enhanced by 2D materials: a comparison between 2D MoS₂ and graphene oxide†

Donghao Xie,‡^a Ding-Kun Ji,‡^b Yue Zhang,^bc Jun Cao,^a Hu Zheng,^a Lin Liu,^a Yi Zang,^c Jia Li,*^c Guo-Rong Chen,^b Tony D. James

*^d and Xiao-Peng He*^b

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* Corresponding authors

^a Department of Pharmacy & Department of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai, P. R. China

^b Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China
E-mail: xphe@ecust.edu.cn

^c National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, P. R. China
E-mail: jli@simm.ac.cn

^d Department of Chemistry, University of Bath, Bath, UK
E-mail: t.d.james@bath.ac.uk

Abstract

Here we demonstrate that 2D MoS₂ can enhance the receptor-targeting and imaging ability of a fluorophore-labelled ligand. The 2D MoS₂ has an enhanced working concentration range when compared with graphene oxide, resulting in the improved imaging of both cell and tissue samples.

Chemical Communications

Targeted fluorescence imaging enhanced by 2D materials: a comparison between 2D MoS₂ and graphene oxide†

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Targeted fluorescence imaging enhanced by 2D materials: a comparison between 2D MoS₂ and graphene oxide

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