Issue 80, 2016

Cu-Catalyzed hydrophosphorylative ring opening of propargyl epoxides: highly selective access to 4-phosphoryl 2,3-allenols

Abstract

A novel CuI-catalyzed cross-coupling of propargyl epoxides with P(O)H compounds is disclosed. The reaction proceeded efficiently under mild conditions to give 4-phosphoryl 2,3-allenols in good to high yields with excellent selectivity. The utility of the products was demonstrated and a plausible mechanism was also proposed.

Graphical abstract: Cu-Catalyzed hydrophosphorylative ring opening of propargyl epoxides: highly selective access to 4-phosphoryl 2,3-allenols

Supplementary files

Article information

Article type
Communication
Submitted
29 Jun 2016
Accepted
12 Sep 2016
First published
12 Sep 2016

Chem. Commun., 2016,52, 11959-11962

Cu-Catalyzed hydrophosphorylative ring opening of propargyl epoxides: highly selective access to 4-phosphoryl 2,3-allenols

R. Shen, J. Yang, H. Zhao, Y. Feng, L. Zhang and L. Han, Chem. Commun., 2016, 52, 11959 DOI: 10.1039/C6CC05428E

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