The synthesis of a new highly symmetric hexakis adduct of C60 appended with 12 cyclooctyne moieties has been carried out. This compound has been used for the copper-free strain-promoted cycloaddition reaction to a series of azides with excellent yields. This strategy for the obtention of clicked adducts of [60]fullerene is of special interest for biological applications.
![Graphical abstract: Cyclooctyne [60]fullerene hexakis adducts: a globular scaffold for copper-free click chemistry](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6CC05484F&imageInfo.ImageIdentifier.Year=2016)
J. Ramos-Soriano, J. J. Reina, A. Pérez-Sánchez, B. M. Illescas, J. Rojo and N. Martín, Chem. Commun., 2016, 52, 10544 DOI: 10.1039/C6CC05484F
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