Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres

Dong Zhu; Jing Ye; Yue Hu; Hong Mei Wen; An Kang; Yu-Ping Tang; Jun Chen; Chen Xiao Shan; Xiao Bing Cui

doi:10.1039/C6CC06128A

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Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres†

Dong Zhu,

*^a Jing Ye,^a Yue Hu,^a Hong Mei Wen,^a An Kang,^a Yu-Ping Tang,*^a Jun Chen,^a Chen Xiao Shan^a and Xiao Bing Cui^a

Author affiliations

* Corresponding authors

^a School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China
E-mail: dongzhu@njucm.edu.cn, yupingtang@njucm.edu.cn

Abstract

A combined specific enrichment and highly efficient solid-phase tagging approach is presented for heparin detection using boronic acid-functionalized mesoporous silica nanospheres as extraction sorbents and nanoscale reactors. It exhibits a faster reaction time (only 6 min), higher tagging-product purity and lower applicable sample concentration compared with liquid-phase tagging.

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Article information

DOI: https://doi.org/10.1039/C6CC06128A
Article type: Communication
Submitted: 25 Jul 2016
Accepted: 25 Aug 2016
First published: 30 Aug 2016

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Chem. Commun., 2016,52, 11779-11782

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Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres

D. Zhu, J. Ye, Y. Hu, H. M. Wen, A. Kang, Y. Tang, J. Chen, C. X. Shan and X. B. Cui, Chem. Commun., 2016, 52, 11779 DOI: 10.1039/C6CC06128A

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Chemical Communications

Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres†

Abstract

Supplementary files

Article information

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Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres

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