A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a quaternary chiral chlorine-attached carbon centre in high yield with excellent enantioselectivity. The low catalyst loading (1 mol%), broad substrate scope, and facile and valuable transformation of the product highlight the practical utility of this process.
X. Bao, S. Wei, L. Zou, Y. He, F. Xue, J. Qu and B. Wang, Chem. Commun., 2016, 52, 11426 DOI: 10.1039/C6CC06236A
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