Issue 94, 2016
From the journal:

Chemical Communications

Pyrrolic molecular rotors acting as viscosity sensors with high fluorescence contrast†

Seung-Chul Lee,‡a   Jeongyun Heo,‡b   Jong-Wan Ryu,a   Chang-Lyoul Lee,*c   Sehoon Kim,*b   Joon-Sung Tae,d   Byung-Ohk Rhee,d   Sang-Wook Kima  and  O-Pil Kwon*a  

* Corresponding authors

a Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea
E-mail: opilkwon@ajou.ac.kr

b Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea
E-mail: sehoonkim@kist.re.kr

c Advanced Photonics Research Institute (APRI), Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Korea
E-mail: vsepr@gist.ac.kr

d Department of Mechanical Engineering, Ajou University, Suwon, Korea

Abstract

New pyrrolic viscosity sensors exhibit one order of magnitude higher fluorescence contrast compared to that of the conventional phenolic analogues due to the viscosity-sensitive rotation of the asymmetric pyrrole group and successfully demonstrate mapping of intracellular viscosity by fluorescence lifetime imaging microscopy.

Graphical abstract: Pyrrolic molecular rotors acting as viscosity sensors with high fluorescence contrast

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Article information

DOI
https://doi.org/10.1039/C6CC06521J
Article type
Communication
Submitted
08 Aug 2016
Accepted
25 Oct 2016
First published
25 Oct 2016

Chem. Commun., 2016,52, 13695-13698

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Pyrrolic molecular rotors acting as viscosity sensors with high fluorescence contrast

S. Lee, J. Heo, J. Ryu, C. Lee, S. Kim, J. Tae, B. Rhee, S. Kim and O. Kwon, Chem. Commun., 2016, 52, 13695 DOI: 10.1039/C6CC06521J

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