Issue 89, 2016
From the journal:

Chemical Communications

Quantitative and regiocontrolled cross-photocycloaddition of the anticancer drug 5-fluorouracil achieved in a cocrystal†

Andrew J. E. Duncan,a   Roxanne L. Dudovitz,a   Shawna J. Dudovitz,a   Jelena Stojaković,a   S. V. Santhana Mariappanb  and  Leonard R. MacGillivray*a  

* Corresponding authors

a Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA
E-mail: len-macgillivray@uiowa.edu
Fax: +1-319-335-1270
Tel: +1-319-332-3504

b Central NMR Facility, University of Iowa, Iowa City, IA 52242-1294, USA

Abstract

We describe a [2+2] cross-photocycloaddition of the anticancer drug 5-fluorouracil in the solid state that proceeds regioselectively and in quantitative yield. The photocycloaddition occurs in a cocrystal with trans-2,2′-bis(pyridyl)ethylene.

Graphical abstract: Quantitative and regiocontrolled cross-photocycloaddition of the anticancer drug 5-fluorouracil achieved in a cocrystal

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Article information

DOI
https://doi.org/10.1039/C6CC06570H
Article type
Communication
Submitted
09 Aug 2016
Accepted
05 Oct 2016
First published
05 Oct 2016

Chem. Commun., 2016,52, 13109-13111

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Quantitative and regiocontrolled cross-photocycloaddition of the anticancer drug 5-fluorouracil achieved in a cocrystal

A. J. E. Duncan, R. L. Dudovitz, S. J. Dudovitz, J. Stojaković, S. V. S. Mariappan and L. R. MacGillivray, Chem. Commun., 2016, 52, 13109 DOI: 10.1039/C6CC06570H

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