Issue 81, 2016
From the journal:

Chemical Communications

Label-free ratiometric electrochemical detection of the mutated apolipoprotein E gene associated with Alzheimer's disease†

Li Wu,abc   Haiwei Ji,ab   Hanjun Sun,ab   Chao Ding,ab   Jinsong Rena  and  Xiaogang Qu*a  

* Corresponding authors

a Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China
E-mail: xqu@ciac.ac.cn

b University of Chinese Academy of Sciences, Beijing, China

c Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195-1700, USA

Abstract

A novel ratiometric electrochemical nanosensing platform was developed based on graphene and mesoporous hybrid nanomaterials for detection of the mutated apolipoprotein E gene associated with Alzheimer's disease. The introduction of ratiometric assay could cancel out some systematic errors and significantly improved the sensing performance, such as reproducibility, reliability and accuracy.

Graphical abstract: Label-free ratiometric electrochemical detection of the mutated apolipoprotein E gene associated with Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C6CC07099J
Article type
Communication
Submitted
30 Aug 2016
Accepted
14 Sep 2016
First published
14 Sep 2016

Chem. Commun., 2016,52, 12080-12083

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Label-free ratiometric electrochemical detection of the mutated apolipoprotein E gene associated with Alzheimer's disease

L. Wu, H. Ji, H. Sun, C. Ding, J. Ren and X. Qu, Chem. Commun., 2016, 52, 12080 DOI: 10.1039/C6CC07099J

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