Issue 82, 2016

Redox tunable delivery systems: sweet block copolymer micelles via thiol–(bromo)maleimide conjugation

Abstract

Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature allows us to control the release of entrapped hydrophobic Nile red by mixing both OBCPs.

Graphical abstract: Redox tunable delivery systems: sweet block copolymer micelles via thiol–(bromo)maleimide conjugation

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2016
Accepted
19 Sep 2016
First published
19 Sep 2016

Chem. Commun., 2016,52, 12202-12205

Redox tunable delivery systems: sweet block copolymer micelles via thiol–(bromo)maleimide conjugation

A. Petrelli, R. Borsali, S. Fort and S. Halila, Chem. Commun., 2016, 52, 12202 DOI: 10.1039/C6CC07136H

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