Issue 100, 2016
From the journal:

Chemical Communications

Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids†

Yusuke Sato,*a   Hiroki Saito,a   Daisuke Aoki,a   Norio Teramaea  and  Seiichi Nishizawa*a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan
E-mail: nishi@m.tohoku.ac.jp

Abstract

Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.

Graphical abstract: Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

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Article information

DOI
https://doi.org/10.1039/C6CC07236D
Article type
Communication
Submitted
05 Sep 2016
Accepted
17 Nov 2016
First published
17 Nov 2016

Chem. Commun., 2016,52, 14446-14449

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Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

Y. Sato, H. Saito, D. Aoki, N. Teramae and S. Nishizawa, Chem. Commun., 2016, 52, 14446 DOI: 10.1039/C6CC07236D

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